Search results for " 3d models"
showing 6 items of 6 documents
Preclinical models in oncological pharmacology: limits and advantages
2021
A wide range of experimental tumor models, each with distinct advantages and disadvantages, is nowadays available. Due to the inherent differences in their complexity and functionality, the choice of the model is usually dependent on the application. Thus, to advance specific knowledge, one has to choose and use appropriate models, which complexity is largely dependent on the hypotheses to test, that is on the objectives. Whatever the model chosen, the complexity of cancer is such that none of them will be able to fully represent it. In vitro tumor models have provided important tools for cancer research and still serve as low-cost screening platforms for drugs. The improved understanding o…
The Human Biodiversity in the Middle of the Mediterranean. Study of native and settlers populations on the Sicilian context
2020
[IT] Negli ultimi 200.000 anni, la specie umana si è diffusa in tutta la Terra, adattando la sua morfologia e fisiologia a un'ampia gamma di habitat. Lo scheletro umano ha quindi registrato i principali effetti ambientali e di conseguenza i reperti scheletrici assumono grande importanza nell'indagine dei processi evolutivi. Oggi le moderne tecniche di indagini quantitative delle principali caratteristiche morfologiche consentono di metterle in relazione con la variabilità genetica. La posizione geografica della Sicilia, l'isolamento e la sua lunga e dinamica storia di colonizzazione (diversi e numerosi contributi culturali e biologici) hanno creato un contesto peculiare che consente uno stu…
TISSUE ENGINEERING FOR THE DEVELOPMENT OF THREE-DIMENSIONAL INVITRO MODELS OF HUMAN MUCOSAE
2014
Traditional two-dimensional (2D) cell cultures only partially reflect the morpho-molecular pattern of human cells in tissues, and they are also unable to fully mimic the complexity of the in vivo microenvironment. Cell development in in vivo systems differs significantly from classical 2D cell culture models, especially with regard to the morphology, growth kinetics, gene expression and the degree of differentiation. Tissue engineering allows the reproduction of tissues by cell seeding on biocompatible scaffolds, to form a homogenous ...
3D DATA INTEGRATION FOR WEB BASED OPEN SOURCE WebGL INTERACTIVE VISUALISATION
2022
Abstract. Recent advances in open-source geospatial technologies in WebGIS allowed the visualization of a 3D complex environment on the web, exploiting realistic Globe reproduction of the real territorial asset. At the same time, in the field of gaming technologies, the new possibilities offered by open-source WebGL JavaScript libraries allowed the creation of Virtual Reality navigation models on the web. The integration between 3D GIS globe navigation models and VR environment navigation is a solution that offers a further level of detail in web navigation, exploiting the capabilities of web browsers in the best way. This research further contributes to this field, showing a workflow to in…
Characterization of a novel three-dimensional outgrowth model of human bronchial mucosa
2011
Recently it has been hypothesized that a reactivation of the epithelial-mesenchymal trophic unit (EMTU) of the respiratory mucosa, caused by extensive epithelial damage, may be responsible for the pathogenesis of asthma. However, most research on this subject so far has been limited by the unavailability of in vitro models correctly mimicking the three-dimensional architecture of the properly differentiated human bronchial mucosa. For this reason, we have developed a novel 3D outgrowth model, obtained from bronchial biopsies and composed of both human bronchial epithelial cells (goblet and columnar cells) and fibroblasts with their basement membrane. Here we present the preliminary data obt…
Surveying Ancient Maya Buildings in the Forest
2017
During the last few decades, 3D scanning devices and 3D digital image generating technology has been developed to the point where they significantly reduce errors and time during data collection thus making them highly appropriate tools in the field of archaeology. With regards to surveying, terrestrial laser scanning and digital photogrammetry, they are a viable alternative to traditional methods for measuring. Nevertheless, these technologies are rarely used in projects in the Maya region, even though they offer a wide range of applications, which could be explored and utilised in this subtropical environment. This paper presents the results of digital surveying involving two Maya archaeo…